Our indications of endoscopic mucosal resection (EMR) for early gastric cancer (EGC) as a
radical treatment are as follows: 1) histology: intestinal type; 2) macroscopic type: IIa and IIc; …

Research into natural products from the marine environment, including microorganisms, has
rapidly increased over the past two decades. Despite the enormous difficulty in isolating and …

Introduction The optimal timing of tracheotomy in critically ill patients remains a topic of
debate. We performed a systematic review to clarify the potential benefits of early versus late …

BACKGROUND In Japan, endoscopic mucosal resection (EMR) is accepted as a treatment
option for cases of early gastric cancer (EGC) where the probability of lymph node …

Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood
production for their lifetime. Appropriate control of HSC self-renewal is crucial for the …

The 'ataxia telangiectasia mutated'(Atm) gene maintains genomic stability by activating a key
cell-cycle checkpoint in response to DNA damage, telomeric instability or oxidative stress …

Hematopoietic stem cells (HSCs) are maintained in an undifferentiated quiescent state
within a bone marrow niche. Here we show that Foxo3a, a forkhead transcription factor that …

Maintenance of hematopoietic stem cells (HSCs) depends on interaction with their niche.
Here we show that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor …

To date, aggregation of DNA-functionalized gold nanoparticles by hybridization of target
DNA in a cross-linking configuration has been intensively studied. Here, we report that …

Background In patients with acquired aplastic anemia, destruction of hematopoietic cells by
the immune system leads to pancytopenia. Patients have a response to immunosuppressive …