Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …

The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC)
transporter family is one of the most widely recognized mechanisms of multidrug resistance …

Early studies of p53 in neuroblastoma reported infrequent mutations in tumours and cell
lines. Cytoplasmic sequestration was later proposed as an alternative mechanism of …

The treatment of advanced ovarian cancer with taxol is hindered by the development of drug
resistance. The cellular target for taxol is the microtubule that is stabilized by the drug. Taxol …

Abstract The Zero Childhood Cancer Program is a precision medicine program to benefit
children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline …

Background Overexpression of the gene for the multidrug-resistance–associated protein
(MRP) has been linked with resistance to chemotherapeutic agents (multidrug resistance) in …

Neuroblastoma is a frequently lethal childhood tumor in which MYC gene deregulation,
commonly as MYCN amplification, portends poor outcome. Identifying the requisite …

Continuous xenografts from 10 children with acute lymphoblastic leukemia (ALL) were
established in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice …

Myc oncoproteins are commonly upregulated in human cancers of different organ origins,
stabilized by Aurora A, degraded through ubiquitin–proteasome pathway-mediated …

Vinca alkaloids are used extensively in the treatment of childhood acute lymphoblastic
leukemia (ALL) and despite their usefulness, drug resistance remains a serious clinical …