The AgNORs

M Derenzini - Micron, 2000 - Elsevier
The structure and the function of interphase AgNORs and the importance of the “AgNOR”
parameter in tumor pathology have been reviewed. Interphase AgNORs are structural …

Nucleolus, ribosomes, and cancer

L Montanaro, D Treré, M Derenzini - The American journal of pathology, 2008 - Elsevier
The complex aspects linking the nucleolus and ribosome biogenesis to cancer are reviewed
here. The available evidence indicates that the morphological and functional changes in the …

What the nucleolus says to a tumour pathologist

M Derenzini, L Montanaro, D Treré - Histopathology, 2009 - Wiley Online Library
The importance of nucleolar changes in cancer cells is underestimated in tumour pathology.
There is evidence that the nucleolus is the mirror of a series of metabolic changes that …

Nucleolar size indicates the rapidity of cell proliferation in cancer tissues

M Derenzini, D Trerè, A Pession… - The Journal of …, 2000 - Wiley Online Library
In order to define the importance of the nucleolus in tumour pathology, the relationship
between nucleolar size and function and tumour mass growth rate was studied in vivo. Ten …

Nucleolar function and size in cancer cells.

M Derenzini, D Trere, A Pession… - The American journal …, 1998 - ncbi.nlm.nih.gov
We have have studied the relationship between nucleolar function and size and cell
doubling time in cancer cells. Seven human cancer cell lines characterized by different …

[HTML][HTML] The ribosome biogenesis—cancer connection

M Penzo, L Montanaro, D Treré, M Derenzini - Cells, 2019 - mdpi.com
Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place
in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its …

The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells.

M Derenzini, V Sirri, D Trere, RL Ochs - Laboratory investigation; a …, 1995 - europepmc.org
Background The quantity of the silver-stained nucleolar proteins (AgNOR proteins)
measured in situ in cytohistologic preparations is related to the rapidity of cell proliferation …

Ribosome biogenesis and control of cell proliferation: p53 is not alone

G Donati, L Montanaro, M Derenzini - Cancer research, 2012 - AACR
Cell growth is a prerequisite for cell proliferation, and ribosome biogenesis is a limiting factor
for cell growth. In mammalian cells, the tumor suppressor p53 has been shown to induce cell …

Quantity of nucleolar silver-stained proteins is related to proliferating activity in cancer cells.

M Derenzini, A Pession, D Trere - Laboratory Investigation; a …, 1990 - europepmc.org
The relationship between the silver-stained proteins of interphase nucleolar organizer
regions (NORs) and proliferative activity was studied in 12 established cell lines derived …

Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation

…, D Treré, L Montanaro, M Derenzini - Journal of cell …, 2011 - journals.biologists.com
The tumour suppressor p53 negatively controls cell cycle progression in response to
perturbed ribosome biogenesis in mammalian cells, thus coordinating growth with …