[PDF][PDF] Programmed death-ligand 1 immunohistochemistry testing: a review of analytical assays and clinical implementation in non-small-cell lung cancer
Purpose Three programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are
currently approved for treatment of nonНsmall-cell lung cancer (NSCLC). Treatment with …
currently approved for treatment of nonНsmall-cell lung cancer (NSCLC). Treatment with …
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations
…, HJ Broxterman, HSL Chan, WS Dalton, M Dietel… - Cancer research, 1996 - AACR
Multidrug resistance (MDR), especially that associated with overexpression of MDR1 and its
product, P-glycoprotein (Pgp), is thought to play a role in the outcome of therapy for some …
product, P-glycoprotein (Pgp), is thought to play a role in the outcome of therapy for some …
Diagnostic procedures for non-small-cell lung cancer (NSCLC): recommendations of the European Expert Group
M Dietel, L Bubendorf, AMC Dingemans, C Dooms… - Thorax, 2016 - thorax.bmj.com
Background There is currently no Europe-wide consensus on the appropriate preanalytical
measures and workflow to optimise procedures for tissue-based molecular testing of non …
measures and workflow to optimise procedures for tissue-based molecular testing of non …
Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
…, K Engels, C Solbach, I Schrader, M Dietel… - Journal of clinical …, 2010 - ascopubs.org
Purpose Preclinical data suggest a contribution of the immune system to chemotherapy
response. In this study, we investigated the prespecified hypothesis that the presence of a …
response. In this study, we investigated the prespecified hypothesis that the presence of a …
Mucosal flora in inflammatory bowel disease
…, M Ortner, J Weber, U Hoffmann, S Schreiber, M Dietel… - Gastroenterology, 2002 - Elsevier
BACKGROUND & AIMS:: Microorganisms that directly interact with the intestinal mucosa are
obscured by fecal flora and poorly characterized. METHODS:: We investigated the mucosal …
obscured by fecal flora and poorly characterized. METHODS:: We investigated the mucosal …
[PDF][PDF] Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and …
…, H Tesch, S Kümmel, P Sinn, C Jackisch, M Dietel… - J Clin oncol, 2015 - academia.edu
Purpose Modulation of immunologic interactions in cancer tissue is a promising therapeutic
strategy. To investigate the immunogenicity of human epidermal growth factor receptor 2 …
strategy. To investigate the immunogenicity of human epidermal growth factor receptor 2 …
[HTML][HTML] Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical …
…, FR Fritzsche, S Niesporek, C Denkert, M Dietel… - British journal of …, 2008 - nature.com
High activity of histone deacetylases (HDACs) causes epigenetic alterations associated with
malignant cell behaviour. Consequently, HDAC inhibitors have entered late-phase clinical …
malignant cell behaviour. Consequently, HDAC inhibitors have entered late-phase clinical …
[HTML][HTML] A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization …
…, E Brambilla, KJ Busam, RR de Krijger, M Dietel… - Modern Pathology, 2018 - Elsevier
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …
currently causes considerable confusion. A uniform classification framework for NENs at any …
[HTML][HTML] HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing
J Rüschoff, M Dietel, G Baretton, S Arbogast, A Walch… - Virchows Archiv, 2010 - Springer
Trastuzumab-based therapy has been shown to confer overall survival benefit in HER2-
positive patients with advanced gastric cancer in a large multicentric trial (ToGA study) …
positive patients with advanced gastric cancer in a large multicentric trial (ToGA study) …
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression
…, K Bommert, MY Mapara, KJ Winzer, M Dietel… - Nature medicine, 1997 - nature.com
Breast cancers are either primarily resistant to chemotherapy (intrinsic resistance), or
respond to chemotherapy but later recur with a multidrug-resistant phenotype because of …
respond to chemotherapy but later recur with a multidrug-resistant phenotype because of …