Publisher Summary This chapter discusses the mechanisms and roles of apoptosis in
pathology. Necrosis differs from apoptosis in structure, mechanism, and sequelae …

Colorectal cancer (CRC) shows variable underlying molecular changes with two major
mechanisms of genetic instability: chromosomal instability and microsatellite instability. This …

BACKGROUND Endometrial hyperplasia (EH) is a uterine pathology representing a
spectrum of morphological endometrial alterations. It is predominantly characterized by an …

Cell death by apoptosis mediates several important physiologic and pathologic processes
and appears to be intrinsically programmed. Its characteristic features are distinctive …

Reactive aldehydes are common carcinogens. They are also by-products of several
metabolic pathways and, without enzymatic catabolism, may accumulate and cause DNA …

Haematopoietic stem cells (HSCs) regenerate blood cells throughout the lifespan of an
organism. With age, the functional quality of HSCs declines, partly owing to the …

Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late
cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells, the current model …

Our intestinal microbiota harbors a diverse microbial community, often containing
opportunistic bacteria with virulence potential. However, mutualistic host-microbial …

Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to
life, and it can crosslink both DNA and proteins. However, the consequences of its …

Background Post-translational modification of histones resulting in chromatin remodelling
plays a key role in the regulation of gene expression. Here we report characteristic patterns …