User profiles for "author:P D Butcher"
Philip D ButcherProfessor St George's University of London Verified email at sgul.ac.uk Cited by 13988 |
[HTML][HTML] Clinical use of whole genome sequencing for Mycobacterium tuberculosis
Drug-resistant tuberculosis (TB) remains a major challenge to global health and to
healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of …
healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of …
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment
Little is known about the biochemical environment in phagosomes harboring an infectious
agent. To assess the state of this organelle we captured the transcriptional responses of …
agent. To assess the state of this organelle we captured the transcriptional responses of …
[HTML][HTML] High-dose rifapentine with moxifloxacin for pulmonary tuberculosis
A Jindani, TS Harrison, AJ Nunn… - … England Journal of …, 2014 - Mass Medical Soc
Background Tuberculosis regimens that are shorter and simpler than the current 6-month
daily regimen are needed. Methods We randomly assigned patients with newly diagnosed …
daily regimen are needed. Methods We randomly assigned patients with newly diagnosed …
[HTML][HTML] Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum
Background Tuberculous sputum provides a sample of bacilli that must be eliminated by
chemotherapy and that may go on to transmit infection. A preliminary observation that …
chemotherapy and that may go on to transmit infection. A preliminary observation that …
Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence
P Brodin, L Majlessi, L Marsollier… - Infection and …, 2006 - Am Soc Microbiol
The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the
extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10 …
extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10 …
Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays
GR Stewart, L Wernisch, R Stabler… - …, 2002 - microbiologyresearch.org
Regulation of the expression of heat-shock proteins plays an important role in the
pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves …
pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves …
Microarrays Reveal that Each of the Ten Dominant Lineages of Staphylococcus aureus Has a Unique Combination of Surface-Associated and Regulatory Genes
Staphylococcus aureus is the most common cause of hospital-acquired infection. In healthy
hosts outside of the health care setting, S. aureus is a frequent colonizer of the human nose …
hosts outside of the health care setting, S. aureus is a frequent colonizer of the human nose …
[PDF][PDF] Mycobacterial P1-type ATPases mediate resistance to zinc poisoning in human macrophages
H Botella, P Peyron, F Levillain, R Poincloux… - Cell host & …, 2011 - cell.com
Mycobacterium tuberculosis thrives within macrophages by residing in phagosomes and
preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey …
preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey …
Whole genome comparison of Campylobacter jejuni human isolates using a low-cost microarray reveals extensive genetic diversity
N Dorrell, JA Mangan, KG Laing, J Hinds… - Genome …, 2001 - genome.cshlp.org
Campylobacter jejuni is the leading cause of bacterial food-borne diarrhoeal disease
throughout the world, and yet is still a poorly understood pathogen. Whole genome …
throughout the world, and yet is still a poorly understood pathogen. Whole genome …
Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms?
T Hampshire, S Soneji, J Bacon, BW James, J Hinds… - Tuberculosis, 2004 - Elsevier
The majority of individuals infected with TB develop a latent infection, in which organisms
survive within the body while evading the host immune system. Such persistent bacilli are …
survive within the body while evading the host immune system. Such persistent bacilli are …