User profiles for "author:R F Harrison"

Robert F Harrison

University of Sheffield
Verified email at sheffield.ac.uk
Cited by 4357

Evaluation of machine-learning methods for ligand-based virtual screening

B Chen, RF Harrison, G Papadatos, P Willett… - Journal of computer …, 2007 - Springer
Abstract Machine-learning methods can be used for virtual screening by analysing the
structural characteristics of molecules of known (in) activity, and we here discuss the use of …

Impulse coupling to targets in vacuum by KrF, HF, and CO2 single‐pulse lasers

CR Phipps Jr, TP Turner, RF Harrison… - Journal of Applied …, 1988 - pubs.aip.org
We present a laser‐target scaling model which permits approximate prediction of the
dependence of ablation pressure, mechanical coupling coefficient, and related parameters …

Barrett's metaplasia

JA Jankowski, RF Harrison, I Perry, F Balkwill… - The lancet, 2000 - thelancet.com
The rate of oesophageal adenocarcinoma is increasing in the western world and has a poor
prognosis mainly because individuals present at a late stage. Attempts to intervene at an …

Common variants at the MHC locus and at chromosome 16q24. 1 predispose to Barrett's esophagus

Esophageal Adenocarcinoma Genetics Consortium… - Nature …, 2012 - nature.com
Barrett's esophagus is an increasingly common disease that is strongly associated with
reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to …

Clonality, founder mutations, and field cancerization in human ulcerative colitis–associated neoplasia

SJ Leedham, TA Graham, D Oukrif, SAC McDonald… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: The clonality of colitis-associated neoplasia has not been fully
determined. One previous report showed polyclonal origins with subsequent monoclonal …

Free triiodothyronine has a distinct circadian rhythm that is delayed but parallels thyrotropin levels

W Russell, RF Harrison, N Smith… - The Journal of …, 2008 - academic.oup.com
Context: TSH is known to have a circadian rhythm, but the relationship between this and any
rhythm in T4 and T3 has not been clearly demonstrated. Objective: With a view to optimizing …

Advancing donor liver age and rapid fibrosis progression following transplantation for hepatitis C

M Wali, RF Harrison, PJ Gow, D Mutimer - Gut, 2002 - gut.bmj.com
Background and aims: Cirrhosis with liver failure due to hepatitis C virus (HCV) infection is
the most common indication for liver transplantation (LT). Reinfection of the transplanted …

Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility

AT Rovio, DR Marchington, S Donat, HC Schuppe… - Nature …, 2001 - nature.com
Human mitochondrial DNA polymerase, encoded by POLG, contains a polyglutamine tract
encoded by a CAG microsatellite repeat 1, 2. Analysis of POLG genotypes in different …

Artificial neural network models for prediction of acute coronary syndromes using clinical data from the time of presentation

RF Harrison, RL Kennedy - Annals of emergency medicine, 2005 - Elsevier
STUDY OBJECTIVE: Clinical and ECG data from presentation are highly discriminatory for
diagnosis of acute coronary syndromes, whereas definitive diagnosis from serial ECG and …

Is routine episiotomy necessary?

RF Harrison, M Brennan, PM North, JV Reed… - Br Med J (Clin Res …, 1984 - bmj.com
One hundred and eighty one primigravid women delivering vaginally in July and August
1982 in the Rotunda Hospital, Dublin, were randomly allocated to one of two groups …