Post-traumatic stress disorder (PTSD) is the only major mental disorder for which a cause is
considered to be known: that is, an event that involves threat to the physical integrity of …

The last decade of neuroimaging research has yielded important information concerning the
structure, neurochemistry, and function of the amygdala, medial prefrontal cortex, and …

Fear extinction is the decrease in conditioned fear responses that normally occurs when a
conditioned stimulus (CS) is repeatedly presented in the absence of the aversive …

In animals, exposure to severe stress can damage the hippocampus. Recent human studies
show smaller hippocampal volume in individuals with the stress-related psychiatric condition …

Background: Previous studies have used symptom provocation and positron emission
tomography to delineate the brain systems that mediate various anxiety states. Using an …

BACKGROUND: A clinical characteristic of posttraumatic stress disorder (PTSD) is
persistently elevated fear responses to stimuli associated with the traumatic event. The …

Background: Preclinical considerations suggest that treatment with a β-adrenergic blocker
following an acute psychologically traumatic event may reduce subsequent posttraumatic …

This study used quantitative volumetric magnetic resonance imaging techniques to explore
the neuroanatomic correlates of chronic, combat-related posttraumatic stress disorder …

BACKGROUND: Extinction of conditioned fear is thought to form a new safety memory that is
expressed in the context in which the extinction learning took place. Rodent studies …

OBJECTIVE: The purpose of this study was to prospectively evaluate the onset, overlap, and
course of posttraumatic stress disorder (PTSD) and major depression following traumatic …