DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of …

…, J Wang, DS Chervinsky, S Thandla… - … and cellular biology, 1997 - Am Soc Microbiol
A distinct population of therapy-related acute myeloid leukemia (t-AML) is strongly
associated with prior administration of topoisomerase II (topo II) inhibitors. These t-AMLs …

ETV6-AML1 translocation breakpoints cluster near a purine/pyrimidine repeat region in the ETV6 gene

SP Thandla, JE Ploski, SZ Raza-Egilmez… - Blood, The Journal …, 1999 - ashpublications.org
Abstract The t (12; 21)(p13; q22) translocation, fusing the ETV6 and AML1 genes, is the most
frequent chromosomal translocation associated with pediatric B-cell precursor acute …

Molecular biology of acute lymphocytic leukemia.

S Thandla, PD Aplan - Seminars in oncology, 1997 - europepmc.org
Acute lymphoblastic leukemia (ALL) has been extensively studied and characterized at a
molecular level. The identification and characterization of molecular lesions associated with …

[PDF][PDF] Therapy-related T cell lymphoblastic lymphoma with t (11; 19)(q23; p13) and MLL gene rearrangement

S Thandla, M Alashari, DM Green, PD Aplan - leukemia, 1999 - academia.edu
6 Pongers-Willemse MJ, Seriu T, Stolz F, d'Aniello E, Gameiro P, Pisa P, Gonzalez M,
Bartram CR, Panzer-Grumayer, Biondi A, San Miguel JF, van Dongen JJM. Primers and …

Pseudo-rearrangement of the MLL gene at chromosome 11q23: a cautionary note on genotype analysis of leukaemia patients.

M Stanulla, HJ Schünemann, S Thandla… - Molecular …, 1998 - ncbi.nlm.nih.gov
AIMS: The MLL gene on chromosome 11q23 is frequently disrupted by chromosomal
translocations in association with haematological malignancies. Recently, a specific site …

[PDF][PDF] ETV6-AML1 Translocation Breakpoints Cluster Near a Purine/Pyrimidine

AMW Block, PJ de Jong, PD Aplan, SP Thandla… - Blood, 1999 - academia.edu
The t (12; 21)(p13; q22) translocation, fusing the ETV6 and AML1 genes, is the most
frequent chromosomal translocation associated w ith pediatric B-cell precursor acute …