BRCA1 and BRCA2 proteins: roles in health and disease.
JA Duncan, JR Reeves, TG Cooke - Molecular pathology, 1998 - ncbi.nlm.nih.gov
Abstract Between 5% and 10% of all breast cancer is hereditary, with patients having a
strong family history of the disease. The remaining 90-95% of cases are classed as …
strong family history of the disease. The remaining 90-95% of cases are classed as …
[HTML][HTML] Follow-up in breast cancer: does routine clinical examination improve outcome? A systematic review of the literature
DA Montgomery, K Krupa, TG Cooke - British journal of cancer, 2007 - nature.com
Multiple guidelines exist for the follow-up of breast cancer, with no agreement on frequency
or duration. The contribution of routine clinical examination for the detection of potentially …
or duration. The contribution of routine clinical examination for the detection of potentially …
Expression of the HER1–4 family of receptor tyrosine kinases in breast cancer
EGFr/HER1 and c‐erbB‐2/HER2 expression are associated with poor prognosis in breast
cancer. The type I receptor tyrosine kinase (RTK) family to which they belong has four …
cancer. The type I receptor tyrosine kinase (RTK) family to which they belong has four …
[HTML][HTML] Alternative methods of follow up in breast cancer: a systematic review of the literature
DA Montgomery, K Krupa, TG Cooke - British Journal of Cancer, 2007 - nature.com
Regular clinical follow up after breast cancer is a common practice. Evidence from
retrospective reviews casts doubt on the efficacy of this practice and the various guidelines …
retrospective reviews casts doubt on the efficacy of this practice and the various guidelines …
Evaluating HER2 amplification and overexpression in breast cancer
JMS Bartlett, JJ Going, EA Mallon… - The Journal of …, 2001 - Wiley Online Library
Abstract The development of Herceptin (Trazumatab) makes testing for HER2 status
important for choosing optimal therapy in breast cancer. This study addresses the precision …
important for choosing optimal therapy in breast cancer. This study addresses the precision …
The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells
Abstract ERBB4/HER4 (referred to here as ERBB4) is a unique member of the epidermal
growth factor receptor (EGFR) family of receptor tyrosine kinases. In contrast to the other …
growth factor receptor (EGFR) family of receptor tyrosine kinases. In contrast to the other …
Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer
Current studies of tumor angiogenesis rely on the concept that endothelium proliferates 30–
40 times faster in tumors than in normal tissues. This evidence is based on histological …
40 times faster in tumors than in normal tissues. This evidence is based on histological …
Interlaboratory Comparison of HER-2 Oncogene Amplification as Detected by Chromogenic and Fluorescence in situ Hybridization
J Isola, M Tanner, A Forsyth, TG Cooke… - Clinical Cancer …, 2004 - AACR
Purpose: Chromogenic in situ hybridization (CISH) is a new modification of the fluorescence
in situ hybridization (FISH) technique for detection of oncogene amplification in archival …
in situ hybridization (FISH) technique for detection of oncogene amplification in archival …
Doppler perfusion index: an interobserver and intraobserver reproducibility study.
K Oppo, E Leen, WJ Angerson, TG Cooke, CS McArdle - Radiology, 1998 - pubs.rsna.org
PURPOSE: To assess the potential of Doppler perfusion index (DPI) measurement as a
routine diagnostic tool in the detection of occult colorectal liver metastases. MATERIALS …
routine diagnostic tool in the detection of occult colorectal liver metastases. MATERIALS …
[HTML][HTML] Outcome and Human Epithelial Growth Factor Receptor (HER) 1-4 status in invasive breast carcinomas with proliferation indices evaluated using …
SM Tovey, CJ Witton, JMS Bartlett, PD Stanton… - Breast Cancer …, 2004 - Springer
Background We have shown previously that whilst overexpression of HER1, 2 and 3 is
associated with poor prognosis in breast cancer, HER4 is associated with a good prognosis …
associated with poor prognosis in breast cancer, HER4 is associated with a good prognosis …