Hyaluronan in human malignancies
RK Sironen, M Tammi, R Tammi, PK Auvinen… - Experimental cell …, 2011 - Elsevier
Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues,
is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of …
is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of …
Lymphocyte infiltrates as a prognostic variable in female breast cancer
S Aaltomaa, P Lipponen, M Eskelinen… - European journal of …, 1992 - Elsevier
The predictive value of lymphocyte infiltrates (LI) was studied in 489 patients with breast
cancer followed-up for over 10 years. LI were positively correlated to axillary lymph-node …
cancer followed-up for over 10 years. LI were positively correlated to axillary lymph-node …
Hyaluronan in human tumors: pathobiological and prognostic messages from cell-associated and stromal hyaluronan
RH Tammi, A Kultti, VM Kosma, R Pirinen… - Seminars in cancer …, 2008 - Elsevier
Cancers are supported by a distinct type of connective tissue stroma, crucial for tumor
survival and advancement. Hyaluronan is a major matrix molecule in the stroma of many …
survival and advancement. Hyaluronan is a major matrix molecule in the stroma of many …
[HTML][HTML] FinnGen provides genetic insights from a well-phenotyped isolated population
Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1%≤ minor …
alleles are often concentrated on a small number of low-frequency variants (0.1%≤ minor …
Genome-wide association study identifies novel breast cancer susceptibility loci
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
FinnGen: Unique genetic insights from combining isolated population and national health register data
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low …
spectrum of damaging alleles in any gene is often concentrated on a small number of low …
[PDF][PDF] Polygenic risk scores for prediction of breast cancer and breast cancer subtypes
N Mavaddat, K Michailidou, J Dennis, M Lush… - The American Journal of …, 2019 - cell.com
Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …
Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies
XR Yang, J Chang-Claude, EL Goode… - Journal of the …, 2011 - academic.oup.com
Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …
A common coding variant in CASP8 is associated with breast cancer risk
A Cox, AM Dunning, M Garcia-Closas… - Nature …, 2007 - nature.com
Abstract The Breast Cancer Association Consortium (BCAC) has been established to
conduct combined case-control analyses with augmented statistical power to try to confirm …
conduct combined case-control analyses with augmented statistical power to try to confirm …
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …