Objective. To identify using proteomic analysis, proteins of altered abundance in the skin of
patients with SSc. Methods. 4 mm excision biopsies were obtained from the forearm …

In the Western world, peripheral vascular disease (PVD) has a high prevalence with high
morbidity and mortality. In a large percentage of these patients, lower limb amputation is still …

In normal adult fibroblasts, transforming growth factor-β (TGFβ) induces the expression of
connective tissue growth factor (CTGF). CTGF independently promotes fibroblast …

Connective tissue growth factor (CTGF) is overexpressed in a variety of fibrotic disorders,
presumably secondary to the activation and production of transforming growth factor-β (TGF …

Connective tissue remodeling provides mammals with a rapid mechanism to repair wounds
after injury. Inappropriate activation of this reparative process leads to scarring and fibrosis …

Patients with scleroderma receiving Iloprost as a treatment for severe Raynaud's
phenomenon report a reduction in skin tightness, suggesting that this drug inhibits skin …

The environmental problem of Microplastics (MPs) pollution poses a great threat to human
and animal health, which has attracted global attention. The physiological integrity of …

Environmental pollutant cadmium (Cd) can cause macrophage dysfunction, and the
imbalance of M1/M2 is involved in the process of tissue fibrosis. In order to explore the effect …

Although the role of transforming growth factor β (TGFβ) in initiating fibrosis is well
established, the role that TGFβ plays in maintaining fibrosis is unclear. The gene encoding …

Microplastics (MPs) have attracted widespread attention as an emerging environmental
pollutant. Especially in aquatic ecosystems, the harm of MPs to aquatic animals has …