Oxidative stress is a key feature in the Alzheimer's disease (AD) brain and manifests as lipid
peroxidation (LPO). Isoprostanes (iPs) are specific and sensitive markers of in vivo LPO. To …

Background The isoprostane 8,12-iso-iPF 2α -VI, a specific marker of in vivo lipid peroxidation,
is increased in Alzheimer disease (AD). The pathological changes associated with AD …

Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia. In its sporadic form, AD results from the combination of genetic factors with different …

Platelets, activated by various agonists, produce microparticles (MP) from the plasma
membrane, which are released into the extracellular space. Although the mechanism of MP …

Microparticles are released during platelet activation in vitro and have been detected in vivo
in syndromes of platelet activation. They have been reported to express both pro- and …

Alzheimer's disease (AD) includes a group of dementing neurodegenerative disorders that
have diverse etiologies but the same hallmark brain lesions. Since oxidative stress may play …

Oxidative modification of low density lipoprotein (LDL) has been implicated in atherogenesis
1. Evidence consistent with this hypothesis includes the presence of oxidized lipids in …

Alzheimer’s disease is one of the most challenging brain disorders and has profound
medical and social consequences. It affects approximately 15 million persons worldwide, and …

Increased brain oxidative stress is a key feature of Alzheimer's disease (AD) and manifests
predominantly as lipid peroxidation. However, clinical evidence that antioxidants can affect …

Traumatic brain injury (TBI) increases susceptibility to Alzheimer's disease (AD), but it is not
known how TBI contributes to the onset or progression of this common late life dementia. To …