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Detection of Epstein-Barr virus in archival Hodgkin's disease specimens
  1. K J Flavell1,
  2. J A Linford1,
  3. J R Flavell1,
  4. P G Murray1,
  5. L S Young1,
  6. K Scott1
  1. 1School of Health Sciences, University of Wolverhampton, Wolverhampton WV1 1DJ, UK

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    The Epstein-Barr virus (EBV) is associated with several malignancies, including endemic Burkitt's lymphoma, undifferentiated nasopharyngeal carcinoma, post-transplant lymphoproliferative disease, and Hodgkin's disease. The “gold standard” for the detection of EBV infection in clinical tissues is RNA in situ hybridisation that targets the abundantly produced Epstein-Barr virus early RNAs (EBERs).1 This approach is effective in the detection of latent EBV infection in routinely processed, paraffin wax embedded histological material, and has been widely used to analyse the association of EBV with …

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